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KMID : 0388120020110040362
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Journal of Korean Society for the Study of Obesity
2002 Volume.11 No. 4 p.362 ~ p.368
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Impact of Weight Change on Hepatic Markers in Overweight, Middle-Aged Patients
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Lee Sang-Yeoup
Choi Sang-Han
Kim Yun-Jin
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Abstract
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Background : This study was aimed at finding out whether weight reduction alone can improve liver function in overweight or obese patients.
Methods : We did a longitudinal, observational study on weight reduction. The study subjects were 57 patients referred to an obesity clinic in whom overweight or obesity is the sole factor causing abnormal liver function and fatty liver. Patients were weighed about 27 months later.
Results : We compared the degree of improvement in hepatic function between Group I that showed weight reduction and Group Ⅱ that showed no-weight reduction. Group I (40) showed no remarkable change in aspartate aminotransferase (AST) and alanine aminotransferase(ALT) levels. But, Group Ⅱ(12) showed higher AST and ALT levels on follow-up visit than initial visit. AST showed statistically significant elevation by 5.2±7.1 IU/L. ALT also showed statistically significant elevation by 6.5±9.9 IU/L
Conclusion : Without weight reduction above 3% during 27 months, overweight patients will have higher elevated AST or ALT than initial visit.
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KEYWORD
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Aspartate transferase, Alanine transferase, Fatty liver, Weight, Overweight, Obesity
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